DM-3189 2HCl
LDN 193189 hydrochloride
CAS: 1435934-00-1
Molecular Formula: C25H24Cl2N6
DM-3189 2HCl - Names and Identifiers
DM-3189 2HCl - Physico-chemical Properties
| Molecular Formula | C25H24Cl2N6 |
| Molar Mass | 479.40426 |
| Solubility | Soluble in DMSO or in Water (up to 5 mg/ml) |
| Appearance | solid |
| Color | Orange-yellow |
| Storage Condition | -20°C |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 2 months. |
| In vitro study | LDN193189 can effectively inhibit the activation of Smad1, Smad5 and Smad8 mediated by BMP4, The IC50 is 5 nM, and can also effectively inhibit the transcriptional activity of BMP I-type receptor ALK2 and alk3, IC50 is 5nM and 30 nM respectively. In addition, a recent study by LDN193189 on persistently activated ALK2 showed that in human arterial endothelial cells, LDN-193189 blocked the production of oxidative free radicals induced by oxidized LDL. |
| In vivo study | Carrying Ad. LDN-193189 (3 mg/kg, I. P.) induced weak left tibia and fibula calcification, visible on day 13, in conditioned caALK2 transgenic mice at 7 postnatal days, the lesion was blocked on day 15 without causing weight loss or growth retardation, spontaneous fractures, decreased bone density, or behavioral abnormalities. LDN193189 forms curved zebrafish embryos by inhibiting bone morphogenetic protein (BMP)6-induced signaling, while having no effect on vascular development. In mice with PCa-118b tumors, LDN-193189 treatment slowed tumor growth and decreased bone formation in the tumors. In LDLR-/-mice, LDN-193189 inhibits the development of atheroma. In addition, LDN-193189 has an inhibitory effect on vascular inflammation, Osteogenic Activity and calcification. |
DM-3189 2HCl - References
| biological activity | LDN193189 HCl (DM-3189) is a selective inhibitor of BMP signaling, it inhibits the transcriptional activity of BMP type I receptors ALK2 and ALK3 with IC50 of 5 nM and 30 nM in C2C12 cells, respectively, and is 200-fold more selective for BMP than for TGF-β. |
| Target | Value |
| ALK2 (C2C12 cells) | 5 nM |
| ALK3 (C2C12 cells) | 30 nM |
Last Update：2024-04-10 22:29:15
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CAS: 1435934-00-1
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Product Name: LDN 193189 hydrochloride Visit Supplier Webpage Request for quotation
CAS: 1435934-00-1
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
CAS: 1435934-00-1
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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